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Polymorphism in rs2229783 of the Alpha 1(XI(6)
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摘要:Table 3. Comparison of Genotype and Allele Frequencies of rs inCOL11A1 among Subjects of Different Clinical Stages of KBDKBD StagesAlleles (%)Genotypes (%)Recessive Model (%)Dominant Model (%) AGAAAGG
Table 3. Comparison of Genotype and Allele Frequencies of rs inCOL11A1 among Subjects of Different Clinical Stages of KBDKBD StagesAlleles (%)Genotypes (%)Recessive Model (%)Dominant Model (%) AGAAAGGGAA + AGGGAAAG + GG I(n = 158) II (n = 85) III (n = 31) χ2 P
In conclusion, the rs polymorphism of theCOL11A1 gene is significantly associated with the risk of KBD but not the severity of KBD in the northwest Han Chinese population, and the expression level of COL11A in cartilage was significantly lower in the KBD group, the A allele of rs may induce a relative increase inCOL11A expression and be implicated as a protective factor against KBD. Our results should lead to a better understanding of the pathogenic mechanism of KBD. In addition, due to the relatively small number of subjects, our findings are considered preliminary and need to be validated in further studies using larger sample sizes of these subpopulations.
The authors acknowledge help with sample collection from the Centers for Disease Control and Prevention of Linyou and Yongshou counties. We also thank the patients and controls for participating in this study.
#Correspondence should be addressed to Prof GUO Xiong, Tel: 86-29-, E-mail:
Biographical note of the first author: SHI Xiao Wei, female, born in 1971, PhD, majoring in molecular mechanisms of cartilage and bone disease.
文章来源:《西北园艺》 网址: http://www.xbyyzz.cn/qikandaodu/2020/0821/434.html
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